English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference[1], only 36 PEG polymers included)
pikeun babagi – pikeun nyalin, nyebarkeun, sarta nyalabarkeun karyana
pikeun nyampurkeun – pikeun ngarobah karyana
Dumasar kana kaayaan di handap:
atribusi – Anjeun kudu ngatribusi karya ku cara nu geus ditangtukeun ku nu nyieun atawa nu méré lisénsi (tapi lain ku jalan nu sigana téh maksa pikeun Anjeun maké éta karya).
https://creativecommons.org/licenses/by/4.0CC BY 4.0 Creative Commons Attribution 4.0 truetrue
↑ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews60 (1): 59-68. PMID17826865.
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