Témbongkeun sumber pikeun Sulfasalazin

{{Penyangkalan-medis}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 460764435
| image = Sulfasalazine.svg
<!--Clinical data-->
| synonyms  = Sulphasalazine
| tradename = Azulfidine, Salazopyrin, Sulazine, others
| Drugs.com = {{drugs.com|monograph|sulfasalazine}}
| MedlinePlus = a682204
| DailyMedID = Sulfasalazine
| pregnancy_AU      = A
| pregnancy_AU_comment = <ref name="Drugs.com Pregnancy">{{cite web | title=Sulfasalazine Use During Pregnancy | website=Drugs.com | date=9 November 2018 | url=https://www.drugs.com/pregnancy/sulfasalazine.html | access-date=24 January 2020}}</ref>
| pregnancy_US      = B
| pregnancy_US_comment = <ref name="Drugs.com Pregnancy" />
| pregnancy_category= 
| routes_of_administration = [[Oral administration|ngaliwatan baham]]
| class = Sulfonamides
| ATCvet            = 
| ATC_prefix = A07
| ATC_suffix = EC01
<!-- Legal status -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU_comment = 
| legal_BR =  <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F-->
| legal_BR_comment = 
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment = 
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment = 
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment = 
| legal_UK = POM
| legal_UK_comment = <ref name="UK sulfasalazine label">{{cite web | title=Sulfasalazine 250mg/5ml Oral Suspension - Summary of Product Characteristics (SmPC) | website=electronic medicines compendium (emc) | date=13 September 2019 | url=https://www.medicines.org.uk/emc/product/413/smpc | access-date=4 December 2019}}</ref><ref name=UKlabel2014 />
| legal_US = Rx-only
| legal_US_comment = 
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment = 
| legal_status      = <!--For countries not listed above-->
<!--Pharmacokinetic data-->
| bioavailability = <15%
| metabolism = 
| elimination_half-life = 5-10 jam
| excretion = 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 599-79-1
| PubChem = 5339
| PubChemSubstance = 
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00795
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10481900
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3XC8GUZ6CB
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00448
| KEGG2_Ref = {{keggcite|correct|kegg}}
| KEGG2 = C07316
| ChEBI = 9334
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 421
<!--Chemical data-->
| IUPAC_name = 2-hydroxy-5-[(''E'')-2-<nowiki/>{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid
| C=18 | H=14 | N=4 | O=5 | S=1
| molecular_weight = 398.394 g/mol
| SMILES = C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NCEXYHBECQHGNR-UHFFFAOYSA-N
| melting_point = 240
| melting_high = 245
| melting_notes = (dec.)
}}
'''Sulfasalazin''' nyaéta ubar antiperadangan nu dipaké pikeu nurunkeun gejala radang [[Peujit|usus]] atawa ''kolitis ulseratif'' nu mangrupa nyeri beuteung, panas awak, [[diaré]], atawa pendarahan dina bagian tungtung usus gedé (rektum).<ref name=":0">{{Cite web|url=https://www.webmd.com/drugs/2/drug-6260/sulfasalazine-oral/details|title=Drugs & Medications|website=www.webmd.com|language=en|accessdate=2020-06-04}}</ref><ref name=":3">{{Cite web|url=https://www.drugbank.ca/drugs/DB00795|title=Sulfasalazine|website=www.drugbank.ca|accessdate=2020-06-04}}</ref>

== Kagunaan ==
Sulfasalazin ieu teu bisa ngubaran kasakit radang usus ngan ngabantuan nurunkeun gejala nu karasa. Salian ti éta, sulfazalazin ogé bisa dipaké pikeun nanganan ''[[rheumatoid arthritis]]'' nu teu bisa diubaran ku pangobatan séjén.<ref name=":0" /> Ubar ieu gawé kucara nguranngan iritasi jeung bengkak di usus gedé, sarta ngabantu ngurangan nyeri [[sendi]], pembengkakan, jeung kakakuan. Pengobatan dini ''artritis rheumatoid'' bisa ngabantu ngurangan atawa nyegah karusakan sendi nu leuwih parna, ku kituna urang bisa ngalakukeun aktifitas sapopoé sacara normal. Ubar ieu dipaké jeung ubar séjén, istirahat, sarta ngalakukeun térapi fisik ka pasén nu can ngaréspon kana ubar séjén (salisilat, ''nonsteroidal anti-inflammatory drugs''- NSAID).<ref name=":0" /><ref name=":1">{{Cite web|url=https://medlineplus.gov/druginfo/meds/a682204.html|title=Sulfasalazine: MedlinePlus Drug Information|website=medlineplus.gov|language=en|accessdate=2020-06-04}}</ref><ref name=":2">{{Cite web|url=https://www.alodokter.com/sulfasalazine|title=Sulfasalazine|website=Alodokter|accessdate=2020-06-04}}</ref> Ubar ieu ogé biasa dipaké pikeun ngubaran jenis panyakit usus lianna nu disebut panyakit ''[[Crohn]].''<ref name=":2" />

== Cara maké ==
Nginum ubar ieu ngaliwatan [[baham]],tablét atawa kapsul salut enterik sulfasalazin hadéna diinum sanggeus dahar ku sagelas cai hérang ( 8 ons nepi ka240 ml) atawa saluyu jeung nu dianjurkeun ku [[dokter]].<ref name=":0" /><ref>{{Cite web|url=https://www.drugs.com/mtm/sulfasalazine.html|title=Sulfasalazine Uses, Side Effects & Warnings|website=Drugs.com|language=en|accessdate=2020-06-04}}</ref> Telen tablét atawa kapsul sacara utuh, tong dibubukeun atawa digayem heula kusabab cara éta bisa ningkatkeun kamungkinan nyeri [[beuteung]]. Pikeun nyingkahan nyeri beuteung, biasana dokter bakal ningkatkeun dosis sacara saeutik-saeutik , dosis dumasar kana kaayaan kaséhatan pasén, sarta réspon kana térapi, sadengkeun pikeun budak leutik dosis gumantung kana beurat awak pasén.<ref name=":1" /><ref name=":2" /> Usahakeun nginum ubar ieu dina waktu nu saru unggal poéna, mun kapohoan teu nginum ieu ubar, gera inum ubar ieu mun sakirana jarak ka nginum nu satuluyna jauh kénéh, mun geus deukeut jarakna ulah diinum sarta ulah ngagandakeun dosis ubar ieu dina waktu sanggeusna.  Ulah eureun nginum ubar ieu salian ti anjuran dokter.<ref name=":0" /><ref name=":2" />

Inum loba cai wanci keur ngonsumsi ubar ieu, kusabab cara ieu bisa matuan nyingkahan panyakit batu ginjal. Béré nyaho dokter mun kaayaan euweuh kamajuan atawa beuki parna. Pikeun parawatan ''rheumatoid arthritis'', bisa jadi merlukeun waktu 1-3 bulan saacan urang kamajuan tina gejala. <ref name=":0" />
== Ngaran lian ==
Ieu di handap sababaraha ngaran lian tina sulfasalazalin:<ref name=":3" />

* Salazosulfapiridina
* Salazosulfapyridine
* Salazosulfapyridinum
* Salicylazosulfapyridine
* Sulfasalazin
* Sulfasalazina
* Sulfasalazine
* Sulfasalazinum

== Interaksi ubar Sulfasalazine ==

=== Ubar séjén ===
Interaksi ubar ieu bisa ngarobah gawé ubarna sarta ningkatkeun résiko éfék samping nu leuwih parna.Sok sanajan sababaraha ubar teu bisa dipaké dina waktu nu babarengan, dina kasus séjén dua ubar nu béda bisa jadi meunanng dipaké dina waktu nu barengan sanajan bisa nyababkeun interaksi antar ubar. Penting pikeun ngajéntrékeun heula ka dokter atawa apoteker ngeunaan ubar nu keur dikonsumsi boh vitamin atawa ubar herval.  Ieu di handap sababaraha conto interaksi ubar antara sulfasalazin jeung ubar lianna:

*''[[Methenamine]]'': Teu dianjurkeun pikeun maké ubar ieu babarengan jeung sulfasalazin. Ngagabungkeu ubar ieu bisa nyababkeun kabentukna kristal dina urin.<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/methenamine-with-sulfasalazine-1582-0-2130-0.html|title=Methenamine and sulfasalazine Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Mercaptopurine]]'': Maké ubar ieu babarengan jeung sulfasalazin bisa ningkatkeun résiko mercaptopurine. tepungan dokter mun anjeun ngarasakeun gejala kayaning diaré, lieur, sebel, pendarahan, panas awak, katirisan atawa tanda-tanda interaksi lianna. Lamun dokter ngaresepkeun ubar ieu babarengan, anjeun butuh dosis nu disaluyukeun atawa tes hudud pikeun pamakéan ubar ieu. <ref>{{Cite web|url=https://www.drugs.com/drug-interactions/mercaptopurine-with-sulfasalazine-1565-0-2130-0.html|title=Mercaptopurine and sulfasalazine Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Teriflunomide]]'': Bisa ningkatkeun résiko éfék samping nu mangaruhan fungsi sumsum tulang anjeun, nu matak jumlah sél-sél getih nu béda jumlahna jadi saeutik. Bisa nyababkeun anjeun anémia, masalah pendarahan, atawa inféksi.<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/sulfasalazine-with-teriflunomide-2130-0-3417-0.html|title=Sulfasalazine and teriflunomide Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Tolazamide]]'': Pamakéan sulfasalazin jeung insulin bisa ningkatkeun résiko hipoglikemia, atawa gula darah rendah. Gejalana kaasup nyeri sirah, lieur, tunduh, geumpeur, kabingungan, trémor, leuleus, sarta ngaratug jantung.<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/sulfasalazine-with-tolazamide-2130-0-2209-0.html|title=Sulfasalazine and tolazamide Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Digoxi]]'': Pamakéan sulfasalazin jeung digoxin bisa ngurangan pangaruh digoxin.<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/digoxin-with-sulfasalazine-883-0-2130-0.html|title=Digoxin and sulfasalazine Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Cyclosporine]]'': Lamun dipaké babrengann jeung ieu ubar bisa ningkatkeunn résiko panolakan organ patali jeung tingkat cyclosporine nu leutik. Kombinasi ieu bisa ningkatkeun éfék samping bahaya pikeun ginjal. <ref>{{Cite web|url=https://www.drugs.com/drug-interactions/cyclosporine-with-sulfasalazine-763-0-2130-0.html|title=Cyclosporine and sulfasalazine Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>
*''[[Warfarin]]'': Pamakéan warfarin bareng jeung sulfasalazin bisa ningkatkeun résiko pendarahan, utamana pikeun nu geus kolot atawa nu miboga gangguan ginjal.<ref>{{Cite web|url=https://www.drugs.com/drug-interactions/sulfasalazine-with-warfarin-2130-0-2311-0.html|title=Sulfasalazine and warfarin Drug Interactions|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>.

=== Kaayan kaséhatan ===
Ayana masalah kaséhatan lianna dina awak bisa mangaruhan pamakéan ieu ubar. J'entr'ekeun ka dokter mun anjeun miboga kaayan kaséhatan kayaning:<ref name=":4">{{Cite web|url=https://hellosehat.com/obatan-suplemen/obat/sulfasalazine/|title=Sulfasalazine : Fungsi, Dosis, Efek Samping, Cara Pakai|website=Hello Sehat|language=id-ID|accessdate=2020-06-04}}</ref>

* Alérgi kana ubar sulfa atawa ''salicylates''
* Panyumbatan usus
*''[[Porphyria]]'' (masalah dina énzim)
* Panyumbatan dina kandung kemih.
*[[Panyakit Asma|Asma]]: paké kalawan ati-ati kusabab bisa ningkatkeun résiko alérgi.
* Masalah dina [[getih]] atawa [[tulang sumsum]] (misal, ''agranulocytosis'', ''aplastic'' ''anemia'')
* Panyakit [[ginjal]]
* Panyakit [[Kawaya]]/hati
* Kakurangan ''Glucose-6-phosphate dehydrogenase'' (G6PD) —bisa nyababkeun hemolytic [[Anémia|anemia]] (kalainan getih)
* Inféksi: Bisa nurunkeun kamampuan awak dina ngalawan inféksi.

== Éfék samping ==
Éfék samping mangrupa hiji éfék nu teu dipiharep tina ubar. Éfék samping ieu bisa mangrupa-rupa di sababaraha jalma gumantung kana kaayaan panyakit, umur, beurat awak, jinis kelamin, étnis, jeung sababaraha kaayaan kaséhatan lianna. Ieu di handap sababaraha éfék samping nu bisa karasa sanggeus nginum sulfasalazin:<ref name=":2" /><ref>{{Cite web|url=https://www.drugs.com/sfx/sulfasalazine-side-effects.html|title=Sulfasalazine Side Effects: Common, Severe, Long Term|website=Drugs.com|language=en|accessdate=2020-06-05}}</ref>

* Ngarasa teu ngeunah awak
* Ngurangan  napsu dahar
* Nyeri [[sirah]]
* Nyeri [[beuteung]]
*[[Diaré]]
* Batuk
* Hésé [[saré]]
* Ruam [[kulit]] nu karasa ateul
*[[Tinnitus]]
* Nyeri dina baham
* Gangguan indera parasa.
* Nyeri [[otot]]
* Nyeri dada
* Darah dina [[Tai|tinja]] atawa urin
* Kulit malegar 

== Tutumbu luar ==

* [https://www.drugs.com/drug-interactions/sulfasalazine.html Interaksi ubar]
* [https://www.drugs.com/sfx/sulfasalazine-side-effects.html Éfék samping sulfasalazin] 

== Rujukan ==

[[Kategori:Ubar]]