Adrénalin
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(R)-(–)-L-Epinéfrin atawa (R)-(–)-L-adrénalin
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| Ngaran sistimatik (IUPAC) | |
| (R)-4-(1-hidroksi- 2-(métilamino)étil)bénzéna-1,2-diol | |
| Identifiers | |
| Nomer CAS | |
| Sandi ATC | A01 B02 C01 R01 R03 S01 |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| Data kimia | |
| Rumus | C9H13NO3 |
| Mass. mol. | 183.204 g/mol |
| Data farmakokinetik | |
| Bioavailabilitas | Nil (oral) |
| Metabolisme | adrenergic synapse (MAO jeung COMT) |
| Waktu paruh | 2 menit |
| Eksresi | Urin |
| Therapeutic considerations | |
| Kat. kehamilan | |
| Legal status |
Prescription Only (S4)(AU) POM(UK) ?(US) |
| Jalur | IV, IM, éndotrahéa, IC |
Epinéfrin (ogé katelah adrénalin; baca Terminologi) nyaéta hormon jeung neurotransmiter[1] nu boga pancén dina réspon "lawan atawa ngejat" dina sistem saraf simpatétik[2], hiji sanyawa katékolamina, monoamina simpatomimetik nu dihasilkeun ku kelenjar adrénal tina asam amino fénilalanin jeung tirosin.
Istilah épinéfrin diturunkeun tina akar basa Yunani epi- jeung nephros, nu hartina dina ginjal, nujul ka perenah anatomis kelenjarna. Akar basa Latén ad- jeung renes ngandung harti nu sarupa, ku kituna aya istilah adrénalin.
Kimiawan Jepang Jokichi Takamine jeung asisténna Keizo Uenaka sacara mandiri ngudar épinéfrin taun 1900[3][4]. Taun 1901 Takamine bisa ngisolasi jeung ngamurnikeun ieu hormon tina kelenjar adrénal domba jeung sapi[5]. Epinéfrin munggaran disintésis ku Friedrich Stolz jeung Henry Drysdale Dakin, séwang-séwangan taun 1904[4].
Baca ogé
[édit | édit sumber]
Rujukan
[édit | édit sumber]Catetan
[édit | édit sumber]- ↑ Berecek, K. H. and Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Heart and Circulatory Physiology. 242 (4): H593 – H601. Pemeliharaan CS1: Banyak nama: authors list (link)
- ↑ Cannon, W. B. (1929). Am. J. Physiol. 89: 84–107.
- ↑ Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr. 11 (2): 95–102. PMID 12717538.
- 1 2 Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res. 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061.
- ↑ Takamine J (1901). The isolation of the active principle of the suprarenal gland. Great Britain: Cambridge University Press. hlm. xxix–xxx.
Rujukan umum
[édit | édit sumber]- Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach. Philadelphia, PA: Elsevier/Saunders. ISBN 1-4160-2328-3. OCLC 56191776.
- Voet D, Voet J (2004). Biochemistry (Édisi 3rd). USA: Wiley. ISBN 0-471-19350-x. OCLC 154657578.