Aspirin

Aspirin
Data klinis
Pelafalan	acetylsalicylic acid /əˌsiːtəlˌsælɪˈsɪlɪk/
Nama dagang	Bayer Aspirin, many others
Sinonim	Citakan:Infobox drug/localINNvariants
AHFS/Drugs.com	Citakan:Drugs.com
MedlinePlus	a682878
License data	EU EMA: by INN; US DailyMed: Acetylsalicylic_acid; US FDA: Aspirin;
Kategori; kehamilan	AU: C ; US: N (Teu dipikanyaho) ;
Jalur; pemberian	by mouth, rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
Kode ATC	A01AD05 (WHO) B01AC06, N02BA01;
Legal status
Legal status	AU: OTC except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.; UK: General sales list (GSL, OTC) ; US: OTC / Rx-only;
Pharmacokinetic data
Bioavailabilitas	80–100%
Ikatan protein	80–90%
Métabolismeu	Liver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.
Eliminasi waktu-paruh	Dose-dependent; 2 h to 3 h for low doses (100 mg or less), 15 h to 30 h for large doses.
Eksresi	Urine (80–100%), sweat, saliva, feces
Identifiers
	Nama IUPAC 2-Acetoxybenzoic acid;
Nomor CAS	50-78-2 ;
PubChem CID	2244;
IUPHAR/BPS	4139;
DrugBank	DB00945 ;
ChemSpider	2157 ;
UNII	R16CO5Y76E;
KEGG	D00109 ; C01405 ;
ChEBI	CHEBI:15365 ;
ChEMBL	ChEMBL25 ;
PDB ligan	AIN (PDBe, RCSB PDB);
ECHA InfoCard	100.000.059
Chemical and physical data
Rumus	C9H8O4
Massa molar	180.158 g·mol−1
3D model (JSmol)	Interactive image;
Massa jenis	1.40 g/cm3
Titik lebur	136 °C (277 °F)
Titik didih	140 °C (284 °F) (decomposes)
Kelarutan dalam air	3g/L
	SMILES O=C(C)Oc1ccccc1C(=O)O;
	InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) ; Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N ;
(verify)

Aspirin nyaéta salah sahiji ubar nu pangkolotna didunya. Ieu ubar mimiti ka catet dipaké ku bangsa Sumeria jeung Mesir pikeun ubar sapopoé, utama na pikeun ngubaran kanyeri. Jaman bahela mah aspirin téh dijieunna tina pepelakan daun willow.^[5] Hippocrates ogé ngembangkeun aspirin liwat ekstrak ieu pepelakan.^[5] Tuluy, loba pangnalungtik dikembangkeun pikeun néeangan rupa-rupa khasiat ti aspirin jeung dosis nu dipake.^[5] Faktana, jaman kiwari aspirin nu bisa ngubaran loba masal-masalah kasehatan.^[5]

Rujukan

1 2 "Aspirin Use During Pregnancy". Drugs.com. 2 April 2018. Diaksés tanggal 29 December 2019.
1 2 "Zorprin, Bayer Buffered Aspirin (aspirin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Diarsipkeun ti vérsi aslina tanggal 7 April 2014. Diaksés tanggal 3 April 2014.
1 2 3 Brayfield, A, éd. (14 January 2014). "Aspirin". Martindale: The Complete Drug Reference. Pharmaceutical Press. Diaksés tanggal 3 April 2014.
1 2 Salah ngutip: Tanda <ref> tidak sah; tidak ditemukan teks untuk ref bernama b92
1 2 3 4 "Obat Aspirin, Apa Manfaatnya dan Apa Efek Sampingnya?". Hello Sehat (Dina basa Indonesia). 2017-02-17. Diaksés tanggal 2017-10-20.

[Drugs.com_Pregnancy-1] 1 2 "Aspirin Use During Pregnancy". Drugs.com. 2 April 2018. Diaksés tanggal 29 December 2019.

[MSR-2] 1 2 "Zorprin, Bayer Buffered Aspirin (aspirin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Diarsipkeun ti vérsi aslina tanggal 7 April 2014. Diaksés tanggal 3 April 2014.

[MD-3] 1 2 3 Brayfield, A, éd. (14 January 2014). "Aspirin". Martindale: The Complete Drug Reference. Pharmaceutical Press. Diaksés tanggal 3 April 2014.

[b92-4] 1 2 Salah ngutip: Tanda <ref> tidak sah; tidak ditemukan teks untuk ref bernama b92

[:0-5] 1 2 3 4 "Obat Aspirin, Apa Manfaatnya dan Apa Efek Sampingnya?". Hello Sehat (Dina basa Indonesia). 2017-02-17. Diaksés tanggal 2017-10-20.

[1]

[2]

[3]

[4]

[5]