Oméprazol
(dialihkeun ti Omeprazol)
Oméprazol nyaéta ubar anu umum digunakeun dina ngubaran panyakit refluks gastroesofagus (GERD), radang lambung atawa maag, radang anu pakait jeung panyakit Crohn, jeung sindrom Zollinger Elisson[1]. Omeprazol kagolong dina ubar jenis inhibitor pompa proton bareng jeung sababaraha ubar jiga lansoprazol jeung rabeprazol[2]
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Oméprazol
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| Ngaran sistimatik (IUPAC) | |
| 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole | |
| Identifiers | |
| Nomer CAS | |
| Sandi ATC | A02 |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| Data kimia | |
| Rumus | C17H19N3O3S |
| Mass. mol. | 345.42 g/mol |
| SMILES | & |
| Data fisika | |
| Titik lééh | 156 °C (313 °F) |
| Data farmakokinetik | |
| Bioavailabilitas | 35–76%[3][4] |
| Ikatan protein | 95% |
| Metabolisme | Hati (nganggo énzim CYP2C19, CYP3A4) |
| Waktu paruh | 1–1.2 jam |
| Eksresi | 80% (urin) 20% (feses) |
| Therapeutic considerations | |
| Licence data |
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| Kat. kehamilan | |
| Legal status |
Prescription Only (S4)(AU) GSL(UK) OTC(US) |
| Jalur | Oral, IV |
Galéri
[édit | édit sumber]-
Tablet oméprazol 20 mg -
Vial injéksi oméprazol 20 mg
Rujukan
[édit | édit sumber]- ↑ "Omeprazole Monograph for Professionals". Drugs.com. Diakses tanggal 2020-04-30.
- ↑ Shin, Jai Moo; Sachs, George (2008-12-01). "Pharmacology of proton pump inhibitors" (dalam bahasa en). Current Gastroenterology Reports 10 (6): 528–534. doi:10.1007/s11894-008-0098-4. ISSN 1534-312X. PMC PMC2855237. PMID 19006606. https://doi.org/10.1007/s11894-008-0098-4.
- ↑ Prilosec Prescribing Information Archived 2010-02-16 di Wayback Machine. AstraZeneca Pharmaceuticals.
- ↑ Vaz-Da-Silva, M; Loureiro, AI; Nunes, T; Maia, J; Tavares, S; Falcão, A; Silveira, P; Almeida, L et al. (2005). "Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions". Clinical Drug Investigation 25 (6): 391–9. doi:10.2165/00044011-200525060-00004. PMID 17532679. http://www.medscape.com/viewarticle/508018.