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Oksitosin

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Oksitosin
Ngaran sistimatik (IUPAC)
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
Identifiers
Nomer CAS 50-56-6
Sandi ATC ?
PubChem 439302
DrugBank DB00107
ChemSpider 388434
Data kimia
Rumus C43H66N12O12S2 
Mass. mol. 1007.19 g/mol
SMILES eMolecules & PubChem
Data farmakokinetik
Bioavailabilitas ?
Ikatan protein 30%
Metabolisme liver and other oxytocinases
Waktu paruh 1–6 min (IV)
~2 h (intranasal)[1][2]
Eksresi Biliary and kidney
Therapeutic considerations
Kat. kehamilan

?

Legal status
Jalur ?

Oksitosin (Oxt) mangrupa hormon péptida sarta neuropéptida. Oksitosin galibna dijieun di hipotalamus sarta dikaluarkeun ku pituitari posterior,[3] anu boga peran dina beungkeutan sosial, réproduksi séksual, ngalahirkeun, sarta mangsa sanggeus ngalahirkeun.[4] Oksitosin dileupaskeun kana aliran getih salaku hormon ngajawab babatekna sérviks jeung rahim nalika ngajuru atawa rangsangan kana puting nalika nyusuan.[5] Oksitosin kapanggih ku Henry Dale taun 1906,[6] anapon struktur molekulna kapanggih taun 1952.[7] Oksitosin ogé dipaké pikeun natambaan/ngalancarkeun anu ngajuru.[8][9][10]

Biokimia

[édit | édit sumber]
OXT
Identifiers
AliasesOXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
External IDsOMIM: 167050 HomoloGene: 55494 GeneCards: OXT
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000915

n/a

RefSeq (protein)

NP_000906

n/a

Location (UCSC)n/an/a
PubMed search[11]n/a
Wikidata
View/Edit Human

Éstrogén geus kanyahoan bisa ngaronjatkeun sékrési oksitosin sarta ngaronjatkeun éksprési reséptorna,reséptor oksitosin, dina uteuk.[12] Di awéwé, sadosis éstradiol geus cukup pikeun ngundakkeun kadar oksitosin dina sirkulasi.[13]

Rujukan

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  1. "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology 37 (9): 1582–6. 2012. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536. 
  2. "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters 33 (1): 21–5. 2012. PMID 22467107. 
  3. Gray's Anatomy: The Anatomical Basis of Clinical Practice (41 ed.). Elsevier Health Sciences. 2015. p. 358. ISBN 978-0-7020-6851-5. 
  4. "Nonsocial functions of hypothalamic oxytocin". ISRN Neuroscience 2013: 179272. 2013. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4045544. 
  5. Chiras DD (2012). Human Biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 978-0-7637-8345-7. 
  6. Dale, H. H (1906). "On some physiological actions of ergot". The Journal of Physiology 34 (3): 163–206. doi:10.1113/jphysiol.1906.sp001148. PMC 1465771. PMID 16992821. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1465771. 
  7. Corey EJ (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 978-1-118-36173-3. 
  8. "Oxytocin: Summary". IUPHAR/BPS guide to pharmacology. International Union of Basic and Clinical Pharmacology. Diakses tanggal 14 December 2016. Endogenous oxytocin is a hormone and neuropeptide, which plays a role in social bonding, sexual reproduction and is required during and after childbirth. Purified oxytocin is used clinically.  Archived 25 Oktober 2020 di Wayback Machine
  9. "Oxytocin". The American Society of Health-System Pharmacists. Diakses tanggal 1 June 2015. 
  10. The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 978-0-19-539981-3. 
  11. "Human PubMed Reference:". 
  12. Goldstein I, Meston CM, Davis S, Traish A (17 November 2005). Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment. CRC Press. pp. 205–. ISBN 978-1-84214-263-9. 
  13. "Oxytocin and Estrogen Receptor β in the Brain: An Overview". Frontiers in Endocrinology 6: 160. 2015. doi:10.3389/fendo.2015.00160. PMC 4606117. PMID 26528239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4606117. 

Bacaeun

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