Oksitosin

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Oksitosin
Ngaran sistimatik (IUPAC)
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
Identifiers
Nomer CAS 50-56-6
Sandi ATC ?
PubChem 439302
DrugBank DB00107
ChemSpider 388434
Data kimia
Rumus C43H66N12O12S2 
Mass. mol. 1007.19 g/mol
SMILES eMolecules & PubChem
Data farmakokinetik
Bioavailabilitas ?
Protein binding 30%
Metabolism liver and other oxytocinases
Half life 1–6 min (IV)
~2 h (intranasal)[1][2]
Excretion Biliary and kidney
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes ?

Oksitosin (Oxt) mangrupa hormon péptida sarta neuropéptida. Oksitosin galibna dijieun di hipotalamus sarta dikaluarkeun ku pituitari posterior,[3] anu boga peran dina beungkeutan sosial, réproduksi séksual, ngalahirkeun, sarta mangsa sanggeus ngalahirkeun.[4] Oksitosin dileupaskeun kana aliran getih salaku hormon ngajawab babatekna sérviks jeung rahim nalika ngajuru atawa rangsangan kana puting nalika nyusuan.[5] Oksitosin kapanggih ku Henry Dale taun 1906,[6] anapon struktur molekulna kapanggih taun 1952.[7] Oksitosin ogé dipaké pikeun natambaan/ngalancarkeun anu ngajuru.[8][9][10]

Biokimia[édit | édit sumber]

OXT
Identifiers
AliasesOXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
External IDsOMIM: 167050 HomoloGene: 55494 GeneCards: OXT
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000915

n/a

RefSeq (protein)

NP_000906

n/a

Location (UCSC)Chr 20: 3.07 – 3.07 Mbn/a
PubMed search[11]n/a
Wikidata
View/Edit Human

Éstrogén geus kanyahoan bisa ngaronjatkeun sékrési oksitosin sarta ngaronjatkeun éksprési reséptorna,reséptor oksitosin, dina uteuk.[12] Di awéwé, sadosis éstradiol geus cukup pikeun ngundakkeun kadar oksitosin dina sirkulasi.[13]

Rujukan[édit | édit sumber]

  1. "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology 37 (9): 1582–6. 2012. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536. 
  2. "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters 33 (1): 21–5. 2012. PMID 22467107. 
  3. Gray's Anatomy: The Anatomical Basis of Clinical Practice (41 ed.). Elsevier Health Sciences. 2015. p. 358. ISBN 978-0-7020-6851-5. 
  4. "Nonsocial functions of hypothalamic oxytocin". ISRN Neuroscience 2013: 179272. 2013. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4045544. 
  5. Chiras DD (2012). Human Biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 978-0-7637-8345-7. 
  6. Dale, H. H (1906). "On some physiological actions of ergot". The Journal of Physiology 34 (3): 163–206. doi:10.1113/jphysiol.1906.sp001148. PMC 1465771. PMID 16992821. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1465771. 
  7. Corey EJ (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 978-1-118-36173-3. 
  8. "Oxytocin: Summary". IUPHAR/BPS guide to pharmacology. International Union of Basic and Clinical Pharmacology. Diakses tanggal 14 December 2016. Endogenous oxytocin is a hormone and neuropeptide, which plays a role in social bonding, sexual reproduction and is required during and after childbirth. Purified oxytocin is used clinically. 
  9. "Oxytocin". The American Society of Health-System Pharmacists. Diakses tanggal 1 June 2015. 
  10. The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 978-0-19-539981-3. 
  11. "Human PubMed Reference:". 
  12. Goldstein I, Meston CM, Davis S, Traish A (17 November 2005). Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment. CRC Press. pp. 205–. ISBN 978-1-84214-263-9. 
  13. "Oxytocin and Estrogen Receptor β in the Brain: An Overview". Frontiers in Endocrinology 6: 160. 2015. doi:10.3389/fendo.2015.00160. PMC 4606117. PMID 26528239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4606117. 

Bacaeun[édit | édit sumber]