Oksitosin

OXT
Identifiers
Aliases	OXT, OT, OT-NPI, OXT-NPI, oxytocin/neurophysin I prepropeptide
External IDs	OMIM: 167050 HomoloGene: 55494 GeneCards: OXT
Gene ontology
Molecular function	• oxytocin receptor binding; • hormone activity; • neurohypophyseal hormone activity; • neuropeptide hormone activity;
Cellular component	• terminal bouton; • extracellular region; • sitoplasma; • secretory granule; • extracellular space;
Biological process	• response to amphetamine; • regulation of digestive system process; • Ejakulasi; • positive regulation of hindgut contraction; • female pregnancy; • positive regulation of penile erection; • response to steroid hormone; • GO:0072468 signal transduction; • response to activity; • regulation of heart rate; • response to sucrose; • positive regulation of ossification; • positive regulation of synapse assembly; • drinking behavior; • hyperosmotic salinity response; • male mating behavior; • positive regulation of cytosolic calcium ion concentration; • response to estradiol; • regulation of sensory perception of pain; • response to cAMP; • response to cocaine; • response to progesterone; • positive regulation of blood pressure; • heart development; • negative regulation of urine volume; • GO:1904578 response to organic cyclic compound; • negative regulation of gastric acid secretion; • positive regulation of prostaglandin secretion; • response to peptide hormone; • maternal behavior; • negative regulation of blood pressure; • Ingatan; • positive regulation of norepinephrine secretion; • perilaku sosial; • response to glucocorticoid; • grooming behavior; • response to prostaglandin E; • eating behavior; • response to ether; • positive regulation of female receptivity; • Saré; • maternal aggressive behavior; • positive regulation of synaptic transmission; • response to electrical stimulus; • positive regulation of uterine smooth muscle contraction; • response to food; • respons terhadap asam retinoat; • positive regulation of renal sodium excretion; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5020
	n/a
	ENSG00000101405
	n/a
	P01178
	n/a
	NM_000915
	n/a
	NP_000906
	n/a
	Wikidata
View/Edit Human



Oksitosin
Ngaran sistimatik (IUPAC)
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
Identifiers
Nomer CAS	50-56-6
Sandi ATC	?
PubChem	439302
DrugBank	DB00107
ChemSpider	388434
Data kimia
Rumus	C₄₃H₆₆N₁₂O₁₂S₂
Mass. mol.	1007.19 g/mol
SMILES	eMolecules & PubChem
Data farmakokinetik
Bioavailabilitas	?
Ikatan protein	30%
Metabolisme	liver and other oxytocinases
Waktu paruh	1–6 min (IV) ~2 h (intranasal)^[1]^[2]
Eksresi	Biliary and kidney
Therapeutic considerations
Kat. kehamilan	?
Legal status
Jalur	?

Oksitosin (Oxt) mangrupa hormon péptida sarta neuropéptida. Oksitosin galibna dijieun di hipotalamus sarta dikaluarkeun ku pituitari posterior,^[3] anu boga peran dina beungkeutan sosial, réproduksi séksual, ngalahirkeun, sarta mangsa sanggeus ngalahirkeun.^[4] Oksitosin dileupaskeun kana aliran getih salaku hormon ngajawab babatekna sérviks jeung rahim nalika ngajuru atawa rangsangan kana puting nalika nyusuan.^[5] Oksitosin kapanggih ku Henry Dale taun 1906,^[6] anapon struktur molekulna kapanggih taun 1952.^[7] Oksitosin ogé dipaké pikeun natambaan/ngalancarkeun anu ngajuru.^[8]^[9]^[10]

Biokimia[édit | édit sumber]

Éstrogén geus kanyahoan bisa ngaronjatkeun sékrési oksitosin sarta ngaronjatkeun éksprési reséptorna,reséptor oksitosin, dina uteuk.^[12] Di awéwé, sadosis éstradiol geus cukup pikeun ngundakkeun kadar oksitosin dina sirkulasi.^[13]

Rujukan[édit | édit sumber]

↑ "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology 37 (9): 1582–6. 2012. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.
↑ "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters 33 (1): 21–5. 2012. PMID 22467107.
↑ Gray's Anatomy: The Anatomical Basis of Clinical Practice (41 ed.). Elsevier Health Sciences. 2015. p. 358. ISBN 978-0-7020-6851-5.
↑ "Nonsocial functions of hypothalamic oxytocin". ISRN Neuroscience 2013: 179272. 2013. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4045544.
↑ Chiras DD (2012). Human Biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 978-0-7637-8345-7.
↑ Dale, H. H (1906). "On some physiological actions of ergot". The Journal of Physiology 34 (3): 163–206. doi:10.1113/jphysiol.1906.sp001148. PMC 1465771. PMID 16992821. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1465771.
↑ Corey EJ (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 978-1-118-36173-3.
↑ "Oxytocin: Summary". IUPHAR/BPS guide to pharmacology. International Union of Basic and Clinical Pharmacology. Diakses tanggal 14 December 2016. Endogenous oxytocin is a hormone and neuropeptide, which plays a role in social bonding, sexual reproduction and is required during and after childbirth. Purified oxytocin is used clinically.
↑ "Oxytocin". The American Society of Health-System Pharmacists. Diakses tanggal 1 June 2015.
↑ The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 978-0-19-539981-3.
↑ "Human PubMed Reference:".
↑ Goldstein I, Meston CM, Davis S, Traish A (17 November 2005). Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment. CRC Press. pp. 205–. ISBN 978-1-84214-263-9.
↑ "Oxytocin and Estrogen Receptor β in the Brain: An Overview". Frontiers in Endocrinology 6: 160. 2015. doi:10.3389/fendo.2015.00160. PMC 4606117. PMID 26528239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4606117.

Bacaeun[édit | édit sumber]

Caldwell HK, Young WS (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). Di Abel L, Lim R. Handbook of neurochemistry and molecular neurobiology. Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2.
Fillod O (2014), "Oxytocin as proximal cause of 'maternal instinct': weak science, post-feminism, and the hormones of mystique", di Schmitz S, Höppner G, Gendered neurocultures: feminist and queer perspectives on current brain discourses, challenge GENDER, 2, Wien: Zaglossus, ISBN 9783902902122.
Yong E (13 November 2015), "The weak science behind the wrongly named moral molecule", The Atlantic .

[pmid22436536-1] "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology 37 (9): 1582–6. 2012. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.

[pmid22467107-2] "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinology Letters 33 (1): 21–5. 2012. PMID 22467107.

[3] Gray's Anatomy: The Anatomical Basis of Clinical Practice (41 ed.). Elsevier Health Sciences. 2015. p. 358. ISBN 978-0-7020-6851-5.

[4] "Nonsocial functions of hypothalamic oxytocin". ISRN Neuroscience 2013: 179272. 2013. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4045544.

[Chi2012-5] Chiras DD (2012). Human Biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 978-0-7637-8345-7.

[6] Dale, H. H (1906). "On some physiological actions of ergot". The Journal of Physiology 34 (3): 163–206. doi:10.1113/jphysiol.1906.sp001148. PMC 1465771. PMID 16992821. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1465771.

[7] Corey EJ (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 978-1-118-36173-3.

[IUPHAR_Oxytocin_summary-8] "Oxytocin: Summary". IUPHAR/BPS guide to pharmacology. International Union of Basic and Clinical Pharmacology. Diakses tanggal 14 December 2016. Endogenous oxytocin is a hormone and neuropeptide, which plays a role in social bonding, sexual reproduction and is required during and after childbirth. Purified oxytocin is used clinically.

[AHFS2015-9] "Oxytocin". The American Society of Health-System Pharmacists. Diakses tanggal 1 June 2015.

[10] The Oxford Handbook of Prosocial Behavior. Oxford University Press. 2015. p. 354. ISBN 978-0-19-539981-3.

[11] "Human PubMed Reference:".

[GoldsteinMeston2005-12] Goldstein I, Meston CM, Davis S, Traish A (17 November 2005). Women's Sexual Function and Dysfunction: Study, Diagnosis and Treatment. CRC Press. pp. 205–. ISBN 978-1-84214-263-9.

[Acevedo-RodriguezMani2015-13] "Oxytocin and Estrogen Receptor β in the Brain: An Overview". Frontiers in Endocrinology 6: 160. 2015. doi:10.3389/fendo.2015.00160. PMC 4606117. PMID 26528239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4606117.

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