Triptopan

l-Triptopan
	; Rumus rangka L-triptopan
modél bal jeung tongkat	modél eusi rohang
Wasta
	Wasta IUPAC Tryptophan
	Wasta IUPAC sistematik asam (2S)-2-amino-3-(1H-indol-3-yl)propanoat
	Wasta lian Asam 2-amino-3-(1H-indol-3-il)propanoat
Pananda
Nomer CAS	73-22-3 ;
Modél 3D (JSmol)	Gambar interaktif; Zwitterion: Gambar interaktif;
ChEBI	CHEBI:16828;
ChEMBL	ChEMBL54976 ;
ChemSpider	6066 ;
DrugBank	DB00150 ;
ECHA InfoCard	100.000.723
IUPHAR/BPS	717;
KEGG	D00020 ;
PubChem CID	6305;
UNII	8DUH1N11BX ;
CompTox Dashboard (EPA)	DTXSID5021419 ;
	InChI InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 Key: QIVBCDIJIAJPQS-VIFPVBQESA-N ;
	SMILES c1[nH]c2ccccc2c1C[C@H](N)C(=O)O; Zwitterion: c1[nH]c2ccccc2c1C[C@H]([NH3+])C(=O)[O-];
Sipat
Rumus kimia	C11H12N2O2
Massa molar	204229 g·mol−1
Kelarutan dina cai	Leyur: 0.23 g/L at 0 °C,; 11.4 g/L at 25 °C,; 17.1 g/L at 50 °C,; 27.95 g/L at 75 °C
Solubilitas	Leyur dina alkohol panas, hidroksida alkali; teu leyur dina kloroform.
Kaasaman (pKa)	2.38 (karboksil), 9.39 (amino)
Suséptibilitas magnétik (χ)	-132.0·10−6 cm3/mol
Farmakologi
Kode ATC	N06AX02 (WHO)
	Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa).
	Rujukan kotak info

Triptopan (lambangna Trp atawa W)^[3] nyaéta asam α-amino anu dipaké dina biosintésis protéin. Triptopan ngandung hiji gugus α-amino, hiji gugus asam α-karboksilat, jeung hiji ranté gigir indol, ku kituna jadi molekul polar anu boga substituén karbon béta aromatik non-polar. Triptopan kaasup ésénsial pikeun manusa, anu hartina teu bisa disintésis/dijieun ku awak sorangan, kudu diala tina dahareun. Triptopan ogé mangrupa prékursor neurotransmiter serotonin, hormon mélatonin, jeung vitamin B3.^[4] Triptopan dikode ku kodon UGG.

Sakumaha asam amino lianna, triptopan ogé zwitterion dina pH pisiologis anu gugus aminona kaprotonan (–NH+3; pK_a = 9,39), anapon asam karboksilatna henteu ( –COO⁻; pK_a = 2,38).^[5]

Baca ogé

Rujukan

1 2 Görbitz, C. H.; Törnroos, K. W.; Day, G. M. (2012). "Single-crystal investigation of L-tryptophan with Z′ = 16". Acta Crystallogr. B. 68 (Pt 5): 549–557. doi:10.1107/S0108768112033484. PMID 22992800.
↑ Dawson RM, et al. (1969). Data for Biochemical Research. Oxford: Clarendon Press. ISBN 0-19-855338-2.
↑ "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkeun ti vérsi aslina tanggal 9 October 2008. Diaksés tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine
↑ Slominski A, Semak I, Pisarchik A, Sweatman T, Szczesniewski A, Wortsman J (2002). "Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells". FEBS Letters. 511 (1–3): 102–6. doi:10.1016/s0014-5793(01)03319-1. PMID 11821057. S2CID 7820568.
↑ "L-tryptophan | C11H12N2O2 - PubChem". pubchem.ncbi.nlm.nih.gov. Diaksés tanggal 22 December 2016.

Bacaan salajengna

Wood RM, Rilling JK, Sanfey AG, Bhagwagar Z, Rogers RD (May 2006). "Effects of tryptophan depletion on the performance of an iterated Prisoner's Dilemma game in healthy adults". Neuropsychopharmacology. 31 (5): 1075–84. doi:10.1038/sj.npp.1300932. PMID 16407905.

Tutumbu kaluar

"KEGG PATHWAY: Tryptophan metabolism - Homo sapiens". KEGG: Kyoto Encyclopedia of Genes and Genomes. 2006-08-23. Diaksés tanggal 2008-04-20.
G. P. Moss. "Tryptophan Catabolism (early stages)". Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Diarsipkeun ti asli tanggal 2003-09-13. Diaksés tanggal 2008-04-20.
G. P. Moss. "Tryptophan Catabolism (later stages)". Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Diarsipkeun ti asli tanggal 2003-09-13. Diaksés tanggal 2008-04-20.
B. Mikkelson; D. P. Mikkelson (2007-11-22). "Turkey Causes Sleepiness". Urban Legends Reference Pages. Snopes.com. Diaksés tanggal 2008-04-20.

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Citakan:Intermédiat métabolisme neurotransmitter Citakan:Serotonérgika Citakan:Triptamina

[Görbitz-1] 1 2 Görbitz, C. H.; Törnroos, K. W.; Day, G. M. (2012). "Single-crystal investigation of L-tryptophan with Z′ = 16". Acta Crystallogr. B. 68 (Pt 5): 549–557. doi:10.1107/S0108768112033484. PMID 22992800.

[isbn0-19-855338-2-2] Dawson RM, et al. (1969). Data for Biochemical Research. Oxford: Clarendon Press. ISBN 0-19-855338-2.

[3] "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkeun ti vérsi aslina tanggal 9 October 2008. Diaksés tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine

[4] Slominski A, Semak I, Pisarchik A, Sweatman T, Szczesniewski A, Wortsman J (2002). "Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells". FEBS Letters. 511 (1–3): 102–6. doi:10.1016/s0014-5793(01)03319-1. PMID 11821057. S2CID 7820568.

[PubChem-5] "L-tryptophan | C11H12N2O2 - PubChem". pubchem.ncbi.nlm.nih.gov. Diaksés tanggal 22 December 2016.

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