Kortison

Kortison
Wasta
Pronunciation	/ˈkɔːrtɪsoʊn/, /ˈkɔːrtɪzoʊn/
	Wasta IUPAC (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
	Wasta lian 17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone
Pananda
Nomer CAS	53-06-5 ;
Modél 3D (JSmol)	Gambar interaktif;
ChEBI	CHEBI:16962 ;
ChEMBL	ChEMBL111861 ;
ChemSpider	193441 ;
ECHA InfoCard	100.000.149
IUPHAR/BPS	5171;
KEGG	D07749 ;
MeSH	Cortisone
PubChem CID	222786;
CompTox Dashboard (EPA)	DTXSID5022857 ;
	InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 Key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N ; InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 Key: MFYSYFVPBJMHGN-ZPOLXVRWBW;
	SMILES O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C;
Sipat
Rumus kimia	C21H28O5
Massa molar	360450 g·mol−1
Titik lebur	220 to 224 °C (428 to 435 °F; 493 to 497 K)
Farmakologi
Kode ATC	H02AB10 (WHO) S01BA03
	Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa).
	verifikasi (naon ieu ?)
	Rujukan kotak info

Artikel ieu lain ngeunaan kortisol.

Kortison nyaéta hormon stériod prégnana (21-karbon) anu dikaluarkeun ku kelenjar adrénal dina nyanghareupan setrés. Sacara wangun kimia, ieu sanyawa kortikostéroid anu deukeut jeung kortisol. Kortison biasa dipaké natambaan rupa-rupa nyeri, ku cara neken sistem imun, ku kituna ngurangan peradangan/inflamasi anu dibarung ku nyeri jeung bareuh lebah nu tatu. Lamun dipaké matuh, kortison bisa bahya ogé. ^[1] ^[2]

Pangaruh jeung mangpaat

Kortison, glukokortikoid, jeung épinéfrin (adrénalin) ngaronjatkeun tekanan getih sarta nyiapkeun awa pikeun réspon lawan atawa ngejat.

Injéksi kortison bisa dipaké pikeun natambaan nyeri & bareuh saharitaeun dina peradangan sendi, urat, atawa bursa, upamana dina tuur, siku, jeung taktak.^[1]

Kortison ogé bisa dipaké pikeun ngurangan réspon imun jalma anu boga kasakit otoimun atawa nalika natambaan cangkok organ pikeun nyegah panolakan cangkokan. Suprési sistem imun ogé penting dina ngubaran kondisi peradangan. ^[3]

Rujukan

↑ ^a ^b "Cortisone shots". MayoClinic.com. Diakses tanggal July 31, 2013.
↑ "Prednisone and other corticosteroids: Balance the risks and benefits". MayoClinic.com. Diakses tanggal 2017-12-21.
↑ Driver, Catherine; Shiel, William. "Cortisone Injection (Corticosteroid Injection) of Soft Tissues & Joints". MedicineNet.com. Diakses tanggal August 7, 2013.

Bacaeun salajengna

Bonagura J., DVM et al. (2000). Current Veterinary Therapy 13. pp. 321–381.
Ingle DJ (October 1950). "The biologic properties of cortisone: a review". J. Clin. Endocrinol. Metab. 10 (10): 1312–54. doi:10.1210/jcem-10-10-1312. PMID 14794756. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=14794756.
Woodward R. B.; Sondheimer F.; Taub D. (1951). "The Total Synthesis of Cortisone". Journal of the American Chemical Society 73 (8): 4057. doi:10.1021/ja01152a551.

[mayo-1] "Cortisone shots". MayoClinic.com. Diakses tanggal July 31, 2013.

[mayorisk2-2] "Prednisone and other corticosteroids: Balance the risks and benefits". MayoClinic.com. Diakses tanggal 2017-12-21.

[3] Driver, Catherine; Shiel, William. "Cortisone Injection (Corticosteroid Injection) of Soft Tissues & Joints". MedicineNet.com. Diakses tanggal August 7, 2013.

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