Glukagon

GCG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1BH0, 1NAU, 2G49, 2M5P, 2M5Q,%%s4ZGM, 4APD, 3IOL, 1D0R,%%s2L64, 2L63
Identifiers
Aliases	GCG, GLP1, glucagon, GRPP, GLP-1, GLP2
External IDs	OMIM: 138030 HomoloGene: 136497 GeneCards: GCG
Gene ontology
Molecular function	• GO:0001948, GO:0016582 Ikatan protein plasma; • pengikatan protein identik; • hormone activity; • glucagon receptor binding; • signaling receptor binding;
Cellular component	• sitoplasma; • endoplasmic reticulum lumen; • extracellular region; • secretory granule lumen; • extracellular space;
Biological process	• negative regulation of execution phase of apoptosis; • G protein-coupled receptor signaling pathway; • regulation of insulin secretion; • cellular response to glucagon stimulus; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of calcium ion import; • positive regulation of histone H3-K4 methylation; • positive regulation of peptidyl-threonine phosphorylation; • feeding behavior; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of protein binding; • cell population proliferation; • GO:0072468 signal transduction; • positive regulation of protein kinase activity; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • protein kinase A signaling; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • response to starvation; • negative regulation of apoptotic process; • regulation of signaling receptor activity; • adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	2641
	n/a
	ENSG00000115263
	n/a
	P01275
	n/a
	NM_002054
	n/a
	NP_002045
	n/a
	Wikidata
View/Edit Human

‹ The template Infobox gene is being considered for merging. ›

Glukagon nyaéta hormon péptida, dihasilkeun ku sél alfa tina pankréas. Gawéna pikeun ngangkat kadar glukosa jeung asam lemak dina aliran getih, sarta dianggap hormon katabolik utama dina awak.^[2] Ieu hormon ogé dipaké pikeun natambaan sababaraha kasakit. Pangaruhna sabalikna ti insulin, anu nurunkeun kadar glukosa ékstrasélular.^[3]

Pankréas ngaluarkeun glukagon nalika kadar insulin (jeung sacara teu langsung glukosa) dina saluran getih kurang teuing. Glukagon ngabalukarkeun haté ngarobah simpenan glikogén jadi glukosa nu dileupaskeun kana aliran getih.^[4] Sabalikna, luhurna kadar glukosa-getih ngarangsang sékrési insulin. Insulin ngamungkinkeun glukosa bisa dicokot jeung dipaké ku jaringan depénden-insulin. Ku kituna, glukagon jeung insulin téh bagian tina sistem eupan balik nu ngajaga stabilna kadar glukosa-getih. Glukagon ngundakkeun dikaluarkeunana énergi; loba dikaluarkeun nalika setrés.^[5] Glukagon asup kana kulawarga sékrétin hormon.

Baca ogé[édit | édit sumber]

Rujukan[édit | édit sumber]

↑ "Human PubMed Reference:".
↑ Voet D, Voet JG. (2011). Biochemistry (4th ed.). New York: Wiley.
↑ Biology. San Francisco: Benjamin Cummings. 2002. ISBN 978-0-8053-6624-2.
↑ Orsay J (2014). Biology 1: Molecules. Examkrackers Inc. p. 77. ISBN 978-1-893858-70-1.
↑ "Minireview: Glucagon in stress and energy homeostasis". Endocrinology 153 (3): 1049–54. March 2012. doi:10.1210/en.2011-1979. PMC 3281544. PMID 22294753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3281544.

Artikel ieu mangrupa taratas, perlu disampurnakeun. Upami sadérék uninga langkung paos perkawis ieu, dihaturan kanggo ngalengkepan.

[1] "Human PubMed Reference:".

[2] Voet D, Voet JG. (2011). Biochemistry (4th ed.). New York: Wiley.

[Campbell-3] Biology. San Francisco: Benjamin Cummings. 2002. ISBN 978-0-8053-6624-2.

[4] Orsay J (2014). Biology 1: Molecules. Examkrackers Inc. p. 77. ISBN 978-1-893858-70-1.

[5] "Minireview: Glucagon in stress and energy homeostasis". Endocrinology 153 (3): 1049–54. March 2012. doi:10.1210/en.2011-1979. PMC 3281544. PMID 22294753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3281544.

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